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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high
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. Both labs have complementarity tools to tackle this novel hypothesis. The van Baarsen lab has access to unique human samples, and the van Egmond lab recently created novel mouse models. By studying
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to different receptors; Study the capacity of nanobodies to block infection by pathogens and develop and test nanobody based vaccines using human in vitro culture systems; Work closely with our collaborators
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